theindychannel.com

Diabetes


Related To Story
Surgeon
Adam Ciesielski/SXC

Master Gene Can Control Fat In The Body

Study: 'Master Regulator' Gene Can Cause Effects In Other Genes Linked To Obesity, Cholesterol

POSTED: 5:03 pm EDT May 17, 2011
UPDATED: 3:42 am EDT May 18, 2011

One gene linked to type 2 diabetes and cholesterol may act as a "master regulator" gene that controls how fat works in the body, according to a study published in Nature Genetics.

Scientists had known that the KLF14 gene is linked to type 2 diabetes and cholesterol but didn't know what role it played in controlling other genes. KLF14 gene is inherited from the mother.

The researchers from King's College London and University of Oxford say that the study indicates that one master gene can cause a "cascade of other metabolic effects in other genes" linked to obesity, HDL cholesterol, insulin and glucose levels. They believe KLF14, thereby "acts as a master switch." They examined 20,000 genes in 800 female twins to determine that association.

The findings mean that the KLF14 gene could become the possible target for treatment efforts to fight against diseases related to metabolism and obesity.

In a press release, a co-author of the study, Mark McCarthy from the University of Oxford, said: "KLF14 seems to act as a master switch controlling processes that connect changes in the behavior of subcutaneous fat to disturbances in muscle and liver that contribute to diabetes and other conditions. We are working hard right now to understand these processes and how we can use this information to improve treatment of these conditions."

The following are comments from our users. Opinions expressed are neither created nor endorsed by TheIndyChannel.com. By posting a comment you agree to accept our Terms of Use. Comments are moderated by the community. To report an offensive or otherwise inappropriate comment, click the "Flag" link that appears beneath that comment. Comments that are flagged by a set number of users will be automatically removed.


Links We Like

Sponsored Content
Employers generally have options when it comes to hiring. Makes sure you present yourself as professionally as possible, or else. More

Vehicles are getting harder to steal outright. Check out the top trends in auto knavery that you need to keep in mind. More

We all like to think of our coworkers as friends, but what happens when you become the target of a coworker's dirty politics? More

The following tips can help your car become a less inviting target and slow down, discourage or actually prevent car theft. More

Sponsored Links

Diabetes Awareness Month

November is Diabetes Awareness Month. Visit our special section, where you'll find animation that illustrates how type 1 and type 2 diabetes differ. You can also calculate your risk for the disease. More

Complications

Diabetes requires constant control and attention, but taking good care of yourself can ward off live-threatening complications. More