Baltimore, MD -- (Sports Network) - Jason Bay homered twice, driving in four runs and Jon Lester pitched seven solid innings as Boston topped Baltimore, 6-3, in the opener of a three-game series from Camden Yards.

Lester (12-4) yielded four hits and one run, striking out five with one walk to record his fifth win in six starts. Jonathan Papelbon earned his 33rd save by working the final 1 1/3 innings.

David Ortiz doubled twice and drove in a run for the Red Sox, who recovered nicely from losing two in a row to Toronto last weekend.

Aubrey Huff finished 2-for-4 with a homer and knocked in all three runs for the Orioles, who dropped their second game in three.

Jeremy Guthrie (10-9) was tagged in the loss for five hits and a pair of runs over seven innings.

After Lester's masterful performance, Sox reliever Manny Delcarmen started the eighth with a three-run cushion but ran into trouble after recording the first two outs.

He walked Nick Markakis and Melvin Mora, paving the way for Papelbon to enter the game. Huff, though, drilled a ball off the base of the wall in left-center to score two. Ramon Hernandez then lifted a lazy fly to right to end the frame.

The Sox picked up two insurance tallies in the ninth to go up 6-3. Dustin Pedroia singled and Ortiz drove him in with a double. A groundout by Kevin Youkilis moved Ortiz to third, and he scored when O's shortstop Alex Cintron was late throwing to the plate on a grounder from Bay.

Papelbon finished off the game by retiring the Orioles in order.

Bay led off the contest with his second homer since coming to the Red Sox, then Jason Varitek added a two-out solo homer.

Huff's solo homer to center with one down in the fourth put the O's on the board, but the home team couldn't put anything else together against the crafty left-hander.

Kevin Millar's one out double in the seventh went by the wayside, as Luke Scott fanned swinging and Jay Payton grounded out.

That proved costly, as Ortiz reached on Millar's fielding error and Bay drilled his second homer of the game to deep center off Rocky Cherry which put Boston ahead 4-1.

Game Notes

Boston has won eight of the 13 meetings this season...For Bay, it was his 12th multi-homer game of his career...Varitek's long ball was his ninth of the year...Sox outfielder J.D. Drew missed the game with stiffness in his back...The Orioles announced that their Sunday, September 7 contest against the Oakland Athletics has been moved back to Saturday, September 6 at 1:05 p.m. (et) to minimize traffic for the Ravens' NFL season-opener. Two games will be played on the 6th as a day-night doubleheader.