CLARK COUNTY, Ind. -  

Two people were killed and two other people were injured early Wednesday in a three-vehicle crash in southern Indiana, state police said.

Shortly after 6:30 a.m., Indiana State Police were called to State Road 60, just east of Deam Lake in Clark County on reports of a fatal crash.

State troopers said a Chevrolet Impala was headed west on S.R. 60 before crossing the center line and hitting a Land Rover SUV headed east.  After hitting the Land Rover, the Impala continued west on S.R. 60 before hitting a Ford F-150 pickup truck that was headed east, police said.

The Clark County Coroner’s Office pronounced the driver of the Impala, Angela K. Berkley, 24, from Bullitt County, Ky., dead at the scene. Two passengers in the Impala, Jason Orme, 33, of Corydon, and Curtis L. Heckel, 24, of Louisville, were taken to University of Louisville hospital with serious injuries, police said.

Heckel later died of his injuries at the hospital.

The driver of the Land Rover, George Napier, 38, of Charlestown, was not injured. He was wearing a seat belt, investigators said.

The driver of the Ford pickup truck, William Piper, 29, of Salem, was flown by medical helicopter to the University of Louisville Hospital with serious injuries. He was not wearing a seat belt, police said.

State Road 60 was shut down for nearly four hours during the investigation, state police said.  

The cause of the crash remained under investigation.